| Autor: |
Guje, Pramod B., Chidrawar, Anil B., Patwari, S. B., Madje, Balaji R., Rajani, Dhanji P., Sangshetti, Jaiprakash N., Damale, Manoj, Pokalwar, Rajkumar U. |
| Předmět: |
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| Zdroj: |
Chemistry & Biology Interface; Nov/Dec2020, Vol. 10 Issue 6, p149-157, 9p |
| Abstrakt: |
A new and convenient method was developed for the synthesis of 3-(1H-benzo(d)imidazole-2-ylthio) methyl-2-chloroquinoline using 2-chloroquinolin-3-carbaldehydes in quantitative yield. The newly prepared compounds were characterized by 1HNMR, IR and Mass spectroscopy. These newly synthesized compounds were studied for antifungal and antibacterial activities. Antibacterial activity study with S. aureus, E. coli, P. aeruginosa and S. pyogenes of compound 4e was found good when compared with Ampicillin as standard. Molecular docking studies have been performed to rationalize the experimentally observed affinity 3-((1H-benzo[d]imidazol-2-ylthio)methyl)-2-chloroquinoline derivatives to gain insights of the mode of inhibition of MurD ligase enzyme. The molecular docking study revealed that derivatives 4e and 4f of 3-((1H-benzo[d]imidazol-2-ylthio)methyl)-2-chloroquinoline are the most active. Antifungal activity of compound 4e was found good with C. Albicans, A. Niger and A. Clavatus when compared with standard Greseofulvin, remaining compounds 4a-d and 4f were not showed any good activities. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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