| Autor: |
Lin, Z., Niu, Y., Jiang, Y., Chen, B., Peng, L., Mi, T., Huang, N., Li, W., Xu, D., Chen, R., Kan, H. |
| Předmět: |
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| Zdroj: |
British Journal of Dermatology; Feb2021, Vol. 184 Issue 2, p261-269, 9p |
| Abstrakt: |
Summary: Background: Exposure to fine particulate matter (with an aerodynamic diameter ≤ 2·5 μm, PM2·5) air pollution has been associated with skin‐related diseases or disorders. Objectives: To evaluate the potential skin‐protective effects of fish‐oil supplementation against PM2·5 exposure. Materials and methods: This is an exploratory analysis based on a pilot randomized, double‐blind, placebo‐controlled trial among 65 healthy young adults between September 2017 and January 2018 in Shanghai, China. We randomly assigned participants to take either fish oil or placebo 2·5 g daily for four consecutive months. Four rounds of skin D‐Squame® tape samples were collected in the last 2 months, and five secondary biomarkers of skin inflammation and oxidative stress were measured. Fixed‐site PM2·5 concentrations on campus were measured in real time. We used linear mixed‐effect models to analyse the associations between short‐term PM2·5 exposure and biomarkers in each group. Results: The 24‐h average PM2·5 concentration was 34·68 ± 15·83 μg m−3. There were generally weaker associations between PM2·5 and biomarkers in the fish‐oil group than in the placebo group, but the associations and the between‐group differences varied by biomarkers and lag periods. Compared with the placebo group, for a 10‐μg m−3 increase in PM2·5 concentration, the increments of interleukin‐1α and carbonyl protein in the fish‐oil group were 41·55% smaller [95% confidence interval (CI) 4·61–78·48%] at lag 0–48 h and 22·01% smaller (95% CI 11·25–32·77%) at lag 0–24 h, respectively. No significant between‐group differences were observed for other biomarkers. Conclusions: This study suggested that dietary fish‐oil supplementation may improve biomarkers of skin inflammation and oxidative‐stress response to short‐term PM2·5 exposure. What is already known about this topic? Fine particulate matter (with an aerodynamic diameter ≤2·5 μm, PM2·5) air pollution may contribute to a range of skin diseases, including inflammatory skin diseases.Few studies have evaluated the potential skin‐protective effects of dietary supplements of anti‐inflammatory and/or antioxidative agents against PM2·5 exposure.There is an urgent need for exploring a simple and effective way to protect skin health against exposure to ambient PM2·5 in areas with severe air pollution. What does this study add? Dietary fish‐oil supplementation may potentially improve biomarkers of skin inflammation and oxidative‐stress response induced by exposure to fine particulate pollution.Findings from this study, if confirmed and extended to vulnerable populations such as patients with existing skin disorders, may have significant clinical and public health implications. Plain language summary available online [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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