Challenges of Discrepant HIV Tests in Pregnant Women in the PrEP era-to Treat or Not to Treat?

Autor:	Wagner, Anjuli D, Kinuthia, John, Dettinger, Julia, Mwongeli, Nancy, Gómez, Laurén, Watoyi, Salphine, Drake, Alison L, Abuna, Felix, Pintye, Jillian, Ochieng, Ben, Odinga, Daniel, John-Stewart, Grace, Baeten, Jared M, GÓmez, Laurén
Předmět:	PREGNANT women CLINICAL trial registries HIV DNA polymerases POLYMERASE chain reaction DIAGNOSIS of HIV infections COMMUNICABLE disease diagnosis HIV prevention PREVENTION of communicable diseases HIV infections ANTI-HIV agents COMMUNICABLE diseases MEDICAL screening PREVENTIVE health services HIGHLY active antiretroviral therapy PREGNANCY complications RESEARCH funding PRENATAL care DISEASE management
Zdroj:	Journal of Infectious Diseases; 1/15/2021, Vol. 223 Issue 2, p234-237, 4p
Abstrakt:	Background: During HIV retesting in antenatal and preexposure prophylaxis (PrEP) care, discrepant results occur, but guidelines are lacking.Methods: In a Kenyan trial implementing antenatal PrEP, if 1 test is reactive, a second is performed; if discrepant, both are repeated; if persistently discrepant, DNA polymerase chain reaction (PCR) is performed.Results: Among 4451 women, 23 265 HIV retesting sessions were performed; 14 (0.06%, 95% confidence interval, 0.03%-0.10%) had discrepant results among 10 individuals; in all 10 initial cases, PCR was negative.Conclusions: Discrepant rapid tests are an expected, rare, and important challenge for antenatal care HIV retesting, with and without PrEP.Clinical Trials Registration: NCT03070600. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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