| Abstrakt: |
Two new diterpenoid derivatives 7 α ,12 β ,17-triacetoxy-6 β, 19-dihydroxy-13 β ,16-spirocicloabiet-8-ene-11,14-dione (1) and 6 β -acetoxy-3 β ,7 α ,12 α -trihydroxy-13 β ,16-spirocicloabiet-8-ene-11,14-dione (2) along with 11 (3 – 13) miscellaneous compounds were isolated from the leaves of Plectranthus ornatus Codd. Their structures were elucidated by spectroscopic analysis and gauge independent atomic orbitals13 C NMR calculations. The isolated compounds were screened for their effects on intestinal motility using guinea-pig ileum and duodenum and by their cytotoxicity against 4 human cancer cell lines (HCT-116, SF-295, PC-3, and HL-60). Compounds 6 and 9 were moderately cytotoxic against HL-60, whereas 6 and 13 were more active on SF-295 and HCT-116. [ABSTRACT FROM AUTHOR] |
