| Autor: |
Al-Saffar, Ali Z., Hadi, Noora A., Khalaf, Hadeel Mohamed |
| Předmět: |
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| Zdroj: |
Indian Journal of Forensic Medicine & Toxicology; Oct-Dec2020, Vol. 14 Issue 4, p2214-2221, 8p |
| Abstrakt: |
Pleurotus eryngii, a type of edible mushroom that exhibit various pharmacological properties, including antioxidant and anticancer effects. In the present study, extracted β-glucan from the P eryngii was tested as an antioxidant and anti-tumor factor. β-glucan was extracted and analyzed by HPLC and FT-IR. Analytical results showed more than 90% similarity in chemical structure and purity. Potential antioxidant activity of β-glucan was examined using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and compared with ascorbic acid. β-glucan confirmed a potential scavenging activity. The anticancer activity of the β-glucan was assessed using different concentrations (6.25 to 400 µg mL-1) on MCF-7 and HepG2 cell lines. P eryngii β-glucan exerted a dose-dependent reduction in MCF-7 and HepG2 cell viability with an IC50 of 280.00 and 539.5 µg mL-1, respectively. At the same time, no significant effect was recorded on normal cell line WRL 68. The obtained results are expected that could be used to develop P eryngii β-glucan as an antitumor drug. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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