| Autor: |
Destri, Christina, Nugraha, Jusak, Amin, Muhammad, Purwanto, Djoko Agus |
| Předmět: |
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| Zdroj: |
Indian Journal of Forensic Medicine & Toxicology; Jan-Mar2021, Vol. 15 Issue 1, p2788-2794, 7p |
| Abstrakt: |
The aim of this study was to verify the phagocytosis activity which displayed in CD11b and B220 markers and also the markers of erythroid 2 nuclear factor related factor 2 (Nrf2) as a key regulatory transcription factor on various antioxidant gene expressions and Superoxide dismutase (SOD) as an antioxidant marker that related with protein. Nrf2 plays an important role to inhibit the ROS accumulation and eliminate free radicals. The active compound of chlorogenic acid in robusta coffee type (Coffea canephora) in Indonesian Coffee and Cocoa Research Center was used in three groups of mice in this study and it was gave different dose in each groups. The assessment samples were taken from the peritoneal fluid of mice than it was analyzed by using Flow Cytometry method to find phagocytosis function and antioxidant activity. The results of ANOVA statistical test was p <0.05 in all parameters, this mean that there was indicated that the active compound of chlorogenic acid in coffee was involved in natural immune system mechanism and it was seen in increasing of phagocytic activity and antioxidant levels. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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