| Autor: |
Fiala, Milan, Lau, Yik Chai Charles, Aghajani, Anthony, Bhargava, Sneha, Aminpour, Eli, Kaczor-Urbanowicz, Karolina Elżbieta, Mirzoyan, Hayk, Nichols, India, Ko, Meng-Wei, Morselli, Marco, Santana, Joslyn, Dang, Johnny, Sayre, James, Paul, Ketema, Pellegrini, Matteo |
| Předmět: |
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| Zdroj: |
Journal of Alzheimer's Disease; 2020, Vol. 75 Issue 3, p993-1002, 10p |
| Abstrakt: |
Background: The cholinesterase inhibitor therapeutics (CI) approved for use in Alzheimer's disease (AD) are palliative for a limited time.Objective: To examine the outcome of AD patients with add-on therapy of the omega-3 fatty acid drink Smartfish.Methods: We performed a prospective study using Mini-Mental State Examination, amyloid-β (Aβ) phagocytosis blood assay, and RNA-seq of peripheral blood mononuclear cells in 28 neurodegenerative patients who had failed their therapies, including 8 subjective cognitive impairment (SCI), 8 mild cognitive impairment (MCI), 2 AD dementia, 1 frontotemporal dementia (FTD), 2 vascular cognitive impairment, and 3 dementia with Lewy bodies (DLB) patients.Results: MCI, FTD, and DLB patients patients volunteered for the addition of a ω-3 fatty acid drink Smartfish protected by anti-oxidants to failing CI therapy. On this therapy, all MCI patients improved in the first year energy transcripts, Aβ phagocytosis, cognition, and activities of daily living; in the long term, they remained in MCI status two to 4.5 years. All FTD and DLB patients rapidly progressed to dementia. On in vivo or in vitroω-3 treatments, peripheral blood mononuclear cells of MCI patients upregulated energy enzymes for glycolysis and citric acid cycle, as well as the anti-inflammatory circadian genes CLOCK and ARNTL2.Conclusion: Add-on ω-3 therapy to CI may delay dementia in certain patients who had failed single CI therapy. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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