| Autor: |
Murillo‐González, Jorge Alfonso, Notario, Belen, Maldonado, Estela, Martinez‐Sanz, Elena, Barrio, M. Carmen, Herrera, Manuel |
| Předmět: |
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| Zdroj: |
Anatomia, Histologia, Embryologia: Journal of Veterinary Medicine Series C; Jan2021, Vol. 50 Issue 1, p84-92, 9p |
| Abstrakt: |
Sheep are recognized as useful species for translational neurodegeneration research, in particular for the study of Huntington disease. There is a lack of information regarding the detailed anatomy and connections of the basal ganglia of sheep, in normal myeloarchitectonics and in tract‐tracing studies. In this work, the organization of the corticostriatal projections at the level of the putamen and globus pallidus (GP) are explored. For the first time, the myeloarchitectonic pattern of connections between the internal (IC) and the external (EC) capsules with the GP have been investigated in the sheep. Formaldehyde‐fixed blocks of the striatum were treated with a metallic stain containing potassium dichromate and visualized using micro‐CT (µ‐CT). The trivalent chromium (Cr3+), attached to myelin phospholipids, imparts a differential contrast to the grey and white matter compartments, which allows the visualization of myelinated fascicles in µ‐CT images. The fascicles were classified according to their topographical location in dorsal supreme fascicles (X, Y, apex) arising from the IC and EC; pre‐commissurally, basal fascicles connecting the ventral part of the EC with the lateral zone of the ventral pallidum (VP) and, post‐commissurally, superior (Z1), middle (Z2) and lower (Z3) fascicles, connecting at different levels the EC with the GP. The results suggest that the presumptive cortical efferent and afferent fibres to the pallidum could be organized according to a dorsal to ventrolateral topography in the sheep, similar to that seen in other mammals. The proposed methodology has the potential to delineate the myeloarchitectonic patterns of nervous systems and tracts. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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