| Autor: |
Maia, Cristiane do Socorro Ferraz, Queiroz, Letícia Yoshitome, Oliveira, Igor Gonçalves, Silva, Carla Cristiane Soares, Cunha, Rodrigo A., Souza‐Monteiro, Deiweson, Ferreira, Maria Karolina Martins, Silveira, Felipe Martins, Silva, Jordana Conceição, Balbinot, Gabriela de Souza, Collares, Fabrício Mezzomo, Martins, Marco Antônio Trevizani, Martins, Manoela Domingues, Lima, Rafael Rodrigues |
| Předmět: |
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| Zdroj: |
Alcoholism: Clinical & Experimental Research; Jan2021, Vol. 45 Issue 1, p56-63, 8p |
| Abstrakt: |
Background: Alcohol (EtOH) intake during adolescence has become an important public health issue. Although the detrimental effects of EtOH intake on the musculoskeletal system are well known, only a few studies have investigated its impact on the stomatognathic system of adolescents. This study aimed to investigate the effect of EtOH binge drinking on the alveolar bone and the long‐term consequences after abstinence. Methods: Adolescent female Wistar rats (35 days old) were exposed to 4 cycles of EtOH binge drinking (3 g/kg/d; 3 days On‐4 days Off) or distilled water (control group). Alveolar bone micromorphology and vertical bone distance were evaluated at 1, 30, and 60 days after that last EtOH intake through X‐ray computed microtomography. The mineral:matrix ratio was assessed through Raman spectroscopy. Results: A decrease in both trabecular thickness and volume ratio, and an increase in trabecular separation were observed at the 1‐day evaluation (immediate withdrawal). After 30 and 60 days, the alveolar bone parameters were found similar to control, except for the mineral:matrix ratio in the long‐term abstinence. Conclusions: EtOH binge drinking during adolescence results in alveolar bone damage that may persist in adulthood, even after abstinence. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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