Effective methylation triage of HPV positive women with abnormal cytology in a middle‐income country.

Autor: Ramírez, Arianis Tatiana, Sánchez, Gloria Inés, Nedjai, Belinda, Agudelo, María Cecilia, Brentnall, Adam R., Cuschieri, Kate, Castañeda, Kelly Melisa, Cuzick, Jack, Lorincz, Attila T., Sanchez (PI), Gloria I, Baena, Armando, Agudelo, Maria C, Tatiana Ramirez, Arianis, Melisa Castañeda, Kelly, Borrero, Mauricio, Riveros, Marcela, Bedoya, Astrid, Botero, Alejandra, Villa, Catalina, Florez, Victor
Předmět:
Zdroj: International Journal of Cancer; Mar2021, Vol. 148 Issue 6, p1383-1393, 11p
Abstrakt: The S5‐methylation test, an alternative to cytology and HPV16/18 genotyping to triage high‐risk HPV‐positive (hrHPV+) women, has not been widely validated in low‐middle‐income countries (LMICs). We compared S5 to HPV16/18 and cytology to detect cervical intraepithelial neoplasia Grade 2 or worse (CIN2+) and CIN3+ in hrHPV+ women selected from a randomized pragmatic trial of 2661 Colombian women with an earlier‐borderline abnormal cytology. We included all hrHPV+ CIN2 and CIN3+ cases (n = 183) age matched to 183
Databáze: Complementary Index