| Autor: |
Moraes, M. O., Pacheco, A. G., Schonkeren, J. J. M., Vanderborght, P. R., Nery, J. A. C., Santos, A. R., Moraes, M. E., Moraes, J. R., Ottenhoff, T. H. M., Sampaio, E. P., Huizinga, T. W. J., Sarno, E. N. |
| Předmět: |
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| Zdroj: |
Genes & Immunity; Nov2004, Vol. 5 Issue 7, p592-595, 4p |
| Abstrakt: |
We have determined IL-10 promoter genotypes of five single-nucleotide polymorphisms (SNPs): T-3575A, A-2849G, C-2763A, -A-1082G and C-819T. The haplotype frequencies were defined in healthy subjects compared to leprosy patients, and analyzed for their occurrence in multi- (MB) vs paucibacillary (PB) as severe and mild forms of leprosy, respectively. Haplotypes defined by three SNP positions (-3575,-2849 and-2763) captured significant differences between controls and patients (P=0.04). The haplotype carrying-3575A,-2849G and-2763C was associated with resistance to leprosy and to the development of severe forms of the disease using either a binomial (controls vs cases, P=0.005, OR=0.35, CI=0.13-0.91) or ordinal (controls vs PB vs MB, P=0.006, OR=0.32, CI=0.12-0.83) model. By contrast, the IL-10 haplotype-3575T/-2849A/-2763C was found to be associated with susceptibility to leprosy per se (P=0.027, OR=2.37, CI=1.04-5.39), but not leprosy type. The data suggest that the IL-10 locus contributes to the outcome of leprosy.Genes and Immunity (2004) 5, 592-595. doi:10.1038/sj.gene.6364122 Published online 12 August 2004 [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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