| Autor: |
HIRONOBU YANAGIE, TAKASHI FUJINO, MASASHI YANAGAWA, TOSHIMITSU TERAO, TAKASHI IMAGAWA, MITSUTERU FUJIHARA, YASUYUKI MORISHITA, RYOUJI MIZUMACHI, YUUJI MURATA, NOVRIANA DEWI, YUUYA ONO, ICHIRO IKUSHIMA, KOJI SEGUCHI, MASASHI NAGATA, YASUMASA NONAKA, YOSHITAKA FURUYA, TOMOYUKI HISA, TAKESHI NAGASAKI, KAZUHIKO ARIMORI, TADAO NAKASHIMA |
| Předmět: |
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| Zdroj: |
In Vivo; Jan/Feb2021, Vol. 35 Issue 1, p239-248, 10p |
| Abstrakt: |
Background/Aim: A mixture of anticancer agents and iodized poppy seed oil (IPSO) has been widely used for intra-arterial chemotherapy of hepatocellular carcinoma. However, the anticancer agents can easily separate from IPSO, so the therapeutic potential is limited. We developed epirubicin-entrapped water-in-oil-in-water emulsion (WOW-Epi) using a double-membrane emulsification technique. Materials and Methods: We delivered WOW-Epi through a hepatic arterial injection to VX2 hepatic tumor rabbit model (1.2 mg/kg). Results: VX2 tumor growth was selectively suppressed in the WOW-Epi-treated group compared with the control treated groups. The accumulation of WOW in nearby cancer cells was confirmed via electron-microscopy. Endocytosis seemed to be the mechanism underlying the uptake of WOW. Conclusion: WOW-Epi led to tumour growth suppression in vivo. WOW does not cause toxicity to arterial vessels. WOW-Epi will be hopefully used for repeated intra-arterial chemotherapy to HCC patients in the near future. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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