| Autor: |
Lauharanta, J., Geiger, J.-M. |
| Předmět: |
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| Zdroj: |
British Journal of Dermatology; Jul1989, Vol. 121 Issue 1, p107-112, 6p |
| Abstrakt: |
Thirty-four patients with extensive psoriasis were treated in a double-blind parallel fashion with either acitretin plus bath PUVA (trimethylpsoralen bath + UVA) or etretinate plus bath PUVA. Each group consisted of 17 patients. The dose of retinoid was 40 mg/day during the 2- week monotherapy phase and subsequently 20 mg/day during the combination treatment. Bath PUVA was given three times a week starting with a UVA dose of 0·06 J/cm2. Remission (> 90% improvement) was achieved in all patients in 6–10 weeks. There were no significant differences in clinical response between the two groups; the mean ± SD PASI score (psoriasis area and severity index) before treatment was 22·6 ± 7·1 in the acitretin-PUVA group and 19·4 ± 7·8 in the etretinate-PUVA group. The corresponding figures after treatment were 0·6 ± 0·6 and 1·0 ± 0·5, respectively. Side-effects related to retinoid treatment were frequent in both groups but they were usually mild and well-tolerated. There was only one case of diffuse alopecia after 8 weeks in the etretinate-PUVA group. Scaling of the palms and soles was seen in six patients in the acitretin-group but only in two patients in the etretinate-group. Triglycerides were elevated in about half of the patients in both groups. The present study shows that acitretin is as effective as etretinate in the combination with bath PUVA. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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