| Abstrakt: |
Background: HIV-TB co-infection continues to be a dual threat worldwide. Aim and objectives: To assess impact of ATT/ART treatment on CD4+T lymphocytes counts among HIV-TB co-infected patients Material and methods: A prospective longitudinal study on a total of 104 HIV and TB coinfected patients was conducted from November, 2017 to October, 2019, in the Department of Microbiology, Regional Institute of Medical Sciences (RIMS), Hospital, Imphal, Manipur, India . Diagnosis of HIV was made as per NACO guidelines, Govt. of India using rapid kit tests. Diagnosis of TB was made as per RNTCP guidelines, Govt. of India. Estimation of CD4 cell counts was carried out by FACS count machine. Follow up of cases done after six months of initiation of ATT/ART. Result: In this study, there were 104 co-infected patients of HIV--TB. Out of the 104 subjects, 67 (64.4%) were from the rural area and the remaining 37(35.6%) were from urban area. There were more of males (72, 69.2%) than the females (32, 30.8%). The maximum number of co-infected patients were 46(42.2%) in the age group of 35-45 years. There were 58 cases of pulmonary TB, 41 cases of extra pulmonary TB and 5 cases of both. All the patients were on ATT and ART therapy. The 2nd CD4 count (283.59 cells /mm3 ) estimations after six months of therapy increases as compared to that of 1st CD4 counts (181.90 cells /mm3) and found statistically significant (p value = 0.0001). Conclusion: In the present study, there was improvement in CD4 counts after the coinfected patients were put on six months ATT/ART therapy. However regular monitoring of CD4 counts is highly required to avoid from other opportunistic infections. [ABSTRACT FROM AUTHOR] |
