Copper-catalyzed enantioselective synthesis of bridged bicyclic ketals from 1,1-disubstituted-4-methylene-1,6-hexanediols and related alkenols.

Autor: Burde, Ameya S., Karyakarte, Shuklendu D., Sylvester, Eric D., Chemler, Sherry R.
Předmět:
Zdroj: Chemical Communications; 1/4/2021, Vol. 57 Issue 1, p105-108, 4p
Abstrakt: Bridged bicyclic ketals display a range of bioactivities. Their catalytic enantioselective synthesis from acyclic 1,1-disubstituted alkene diols is disclosed. This reaction combines asymmetric catalysis with a distal radical migration. Alkynes and arenes undergo the group transfer. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index