| Autor: |
Aggarwal, Ranjana, Singh, Gulshan, Kumar, Virender, Masan, Eakta, Jain, Pranay |
| Předmět: |
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| Zdroj: |
Organic Preparations & Procedures International; 2021, Vol. 53 Issue 1, p42-51, 10p |
| Abstrakt: |
The formation of compound B 5a b is attributed to the I in situ i generation of hydrazine by C-N bond cleavage in B 1 b following the proposed mechanism depicted in Scheme 3. It is worth mentioning that most of these compounds showed anti-Candida activity against I C. albicans. i Interestingly, compounds B 5i b , B 5l b , and B 5o b showed activity against I C. glabrata i , an organism which was resistant to fluconazole. The anti-Candida activity against I C. tropicalis i increases to a significant extent when the hydrogen of the phenyl residue of compound B 5a b is replaced with a chlorine in B 5b b , bromine in B 5d b and fluorine in B 5c b . Anti-Candida and antibacterial activities of the compounds were evaluated by the agar-well diffusion method. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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