| Autor: |
Nguyen, Thi Ngoc, Tran, Thi Phuong Thuy, Vu, Thi Hoang Mai, Nguyen, Hoa Binh, Dao, Nguyet Suong Huyen, Nguyen, Van Giang, Nguyen, Dinh Luyen, Trinh, Nguyen Trieu, Nguyen, Van Hai |
| Předmět: |
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| Zdroj: |
Molbank; Dec2020, Vol. 2020 Issue 4, pM1168-M1168, 1p |
| Abstrakt: |
Sulfones are important building blocks in the construction of biologically active molecules or functional materials. The sulfonyl functional group in sulfones is so versatile that it can act as either a nucleophile, an electrophile, or a radical in different organic reactions. Recently, quinazoline sulfones have been used to build asymmetrical ether derivatives as inhibitors of signaling pathways governed by tyrosine kinases and the epidermal growth factor-receptor. In this paper, we report a facile synthesis of a novel quinazoline sulfone, 6-nitro-7-tosylquinazolin-4(3H)-one (III), using the modified protocol from 7-chloro-6-nitroquinazolin-4(3H)-one (I) and sodium p-toluenesulfinate (II). The structure of the title compound III was determined using mass-spectrometry, FT-IR, 1H-NMR, 13C-NMR, DEPT, HSQC (Heteronuclear single quantum coherence), HMBC (Heteronuclear Multiple Bond Correlation Spectroscopy) spectroscopies, and PXRD analysis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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