Functional prediction and frequency of coding variants in human ACE2 at binding sites with SARS‐CoV‐2 spike protein on different populations.

Autor:	Cruz, Juliana de O., Conceição, Izabela M. C. A., Sousa, Sandra Mara B., Luizon, Marcelo R.
Předmět:	SARS-CoV-2 BINDING sites POPULATION
Zdroj:	Journal of Medical Virology; Jan2021, Vol. 93 Issue 1, p71-73, 3p
Abstrakt:	Functional prediction and frequency of coding variants in human ACE2 at binding sites with SARS-CoV-2 spike protein on different populations Hussain et al1 identified 17 natural coding variants for human angiotensin-converting enzyme 2 ( I ACE2 i ) that were found at positions described as important for binding of ACE2 with SARS-CoV-2 spike protein. The combination of functional predictors could yield more reliable findings mainly regarding to missense variants,2 as previously reported.3 Therefore, we searched for these I ACE2 i variants using other recommended predictors. [Extracted from the article]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu Plný text