| Abstrakt: |
The effect of two types of analgesics ketoprofen and metamizole on some biochemical parameters related to liver and kidney function studied. Twelve Arabi ewes were used with an average weight of 45 kg, aged 6-12 months and were nonpregnant. Animals divided randomly into 3 groups (4/group), control group receive 2 ml of normal saline i.v. injection daily, the (k) group receive (4.4 mg/kg B.W. i.v) of ketoprofen daily, the (M) group receive (55.5 mg/kg B.W.i.v) of metamizole daily, all groups treated for 5 days. Five ml of blood taken from a jugular vein after the 5th day of the experiment and serum was isolate to estimate biochemical parameters, urine also collected onthe same days. The studied parameters were urine creatinine, (GFR), Serum (creatinine, urea, cholesterol, triglyceride, (HDL), Total Protein, Albumin, AST and ALT). The results after 5 days of the experiment were showed a significant (p≤ 0.05) increase in serum triglyceride in (K) group as compared with the control group and serum cholesterol in (K) group as compared to the (M)group. But, there was a significant (p≤ 0.05) decrease in urine creatinine, serum ALT concentrations when compared to the control group. Mitamisol (M) group showed a significant (p ≤ 0.05) increase in serum triglyceride and AST and significant (p≤ 0.05) decrease in GFR, serum (cholesterol and ALT), when compared with the control group. Long term treatment with Ketoprofen and metamizole cause some effect on liver functions when uses at a therapeutic level in Arabi ewes for 5 days or more but there was little influence on kidney function. [ABSTRACT FROM AUTHOR] |
