| Abstrakt: |
Osteoarthritis (OA) or Degenerative Joint Disease (DJD) is the most prevalent form of arthritis, producing a progressive deterioration of the articular structures, chronic disability, and joint pain. From a pathophysiological perspective, OA is considered a "whole joint" disease, including deterioration and loss of the cartilage and meniscal structures, changes in bony structures including the subchondral bone, and synovial inflammation. Over the last four decades, many different mechanisms of degenerative Temporomandibular Joint (TMJ) disease have been proposed in the literature. Most of these alleged mechanisms are based on the premise that overloading of the joint, excessive forces, and trauma play a central role in disrupting the structural integrity of the TMJ structure. Treatment of TMJ OA should take the leading example from the field of rheumatology, identifying well-defined phenotypes to comprehensively explain the wide variety of clinical presentations, etiologies, the inter-individual variability in the progression of the disease, and the diverse clinical responses to treatment. |
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