Generation of Glycosyl Radicals from Glycosyl Sulfoxides and Its Use in the Synthesis of C‐linked Glycoconjugates.

Autor:	Shang, Weidong, Su, Sheng‐Nan, Shi, Rong, Mou, Ze‐Dong, Yu, Guo‐Qiang, Zhang, Xia, Niu, Dawen
Předmět:	GLYCOCONJUGATES SULFOXIDES ARYL iodides HUMIDITY MOIETIES (Chemistry) RADICALS (Chemistry)
Zdroj:	Angewandte Chemie International Edition; 1/4/2021, Vol. 60 Issue 1, p385-390, 6p
Abstrakt:	We here report glycosyl sulfoxides appended with an aryl iodide moiety as readily available, air and moisture stable precursors to glycosyl radicals. These glycosyl sulfoxides could be converted to glycosyl radicals by way of a rapid and efficient intramolecular radical substitution event. The use of this type of precursors enabled the synthesis of various complex C‐linked glycoconjugates under mild conditions. This reaction could be performed in aqueous media and is amenable to the synthesis of glycopeptidomimetics and carbohydrate‐DNA conjugates. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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