| Autor: |
Данилович, Ю. В., Данилович, Г. В., Єсипенко, О. А., Кальченко, В. І., Костерін, С. О. |
| Předmět: |
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| Zdroj: |
Nanosistemi, Nanomateriali, Nanotehnologii; 2020, Vol. 18 Issue 3, p459-464, 6p |
| Abstrakt: |
Chalcone calix[4]arenes C-138, C-137, C-1023, and C-1011 at a concentration of 10 μM inhibit the oxidation of NADH and FADH2 in the electron-transport chain of isolated uterine smooth-muscle mitochondria, depending on the amount of chalcone substitutes. Calix[4]arenes C-1023 and C-1011, having 3 and 4 substituents, respectively, enhance the generation of reactive oxygen species in the mitochondria. The inhibition of the NADH and FADH2 oxidation in the mitochondria reflects the possibility of modulating their energy and, consequently, the functioning of Ca2+-transport systems. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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