| Autor: |
Leonte, R. A., Cocioabă, D., Chilug, L. E., Băruță (Ilie), S. I., Eșanu, T. R., Burghelea, B., Chiriacescu, A., Crăciun, L. S., Niculae, D., Kok, Kuan-Ying, Ng, Yen, Zin, Muhammad Rawi Muhamed, Mahmood, Zal U'yun Wan, Ahmad, Zaiton, Idris, Faridah Mohamad, Mahmoud, Mahdi Ezwan, Sipaun, Susan Maria, Talib, Marina, Leo, Kwee-Wah, Hak, Cik Rohaida Che |
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| Zdroj: |
AIP Conference Proceedings; 2020, Vol. 2295 Issue 1, p1-7, 7p |
| Abstrakt: |
64Cu is a cyclotron-produced radionuclide suitable for positron emission tomography (PET) and internal radiotherapy. We have been focused on 64Cu radioisotope due to its favorable nuclear characteristics (β+ emission, 18% and β− emission, 39%). Moreover, the electron capture (43%) implies Auger electron emission with high linear energy transfer in the targeted cells. Also, the 12.7 hours half-life allows a good uptake and distribution of the radiopharmaceuticals to obtain qualitative images with high contrast. The production of no-carrier-added 64Cu via the 64Ni(p,n)64Cu nuclear reaction using a variable energy cyclotron (TR-19, ACSI, Canada) was studied in our work involving the implementation of a fully automated solid target irradiation and processing system. In this paper we report the validation of the process for the automated production and purification of 64Cu produced in a variable energy (14-19 MeV) cyclotron, using a commercially available automated solid target system (ALCEO, Comecer S.p.A, Italy), comprising modules for electrodeposition, pneumatic transfer, irradiation unit, dissolving and purification. The obtained 64CuCl2 solution complies with the requirements of a radiopharmaceutical for medical applications. The process is to be translated for production of other copper radioisotopes of medical interest. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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