Microcytosis in patients with haemoglobin C trait: is α‐thalassaemia trait to blame?

Autor:	Forté, Stéphanie, Eng, Barry, Verhovsek, Madeleine, Soulières, Denis, Waye, John S.
Předmět:	HEMOGLOBINS BLOOD cell count DELETION mutation CHILDBEARING age ERYTHROCYTES
Zdroj:	British Journal of Haematology; Dec2020, Vol. 191 Issue 5, pe129-e131, 3p
Abstrakt:	Microcytosis in patients with haemoglobin C trait: is -thalassaemia trait to blame? Keywords: haemoglobinopathies; haemoglobin C trait; microcytosis; HbC trait; -thalassaemia trait EN haemoglobinopathies haemoglobin C trait microcytosis HbC trait -thalassaemia trait e129 e131 3 12/07/20 20201201 NES 201201 Haemoglobin C (HbC) is the third most common variant haemoglobin worldwide after haemoglobin S and E. In some regions of West Africa, the allele frequency is >20%.1 The -globin Glu6Lys substitution decreases HbC solubility, causing sickle cell disease when co-inherited with haemoglobin S. However, HbC trait is asymptomatic and displays normal haemoglobin concentration. Haemoglobinopathies, haemoglobin C trait, microcytosis, HbC trait, -thalassaemia trait. [Extracted from the article]
Databáze:	Complementary Index
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