| Autor: |
Hahn, P., Lindsten, T., Lyubarsky, A., Ying, G.-S., Pugh, E. N., Thompson, C. B., Dunaief, J. L. |
| Předmět: |
|
| Zdroj: |
Cell Death & Differentiation; Nov2004, Vol. 11 Issue 11, p1192-1197, 6p |
| Abstrakt: |
Photoreceptors of bax-/-bak-/- but neither bax-/- mice nor bak-/- mice are protected from developmental apoptosis, suggesting that bax-/-bak-/- photoreceptors may also be protected from pathologic apoptosis. To test this possibility, we exposed bax-/-bak-/- and bax-/- mice to bright light, which normally induces photoreceptor death. Photoreceptors in bax-/-bak-/- mice were protected from death compared to bax-/- mice as indicated by a reduction in the number of TUNEL-positive photoreceptor nuclei 24?h following light damage and almost complete preservation of photoreceptors 7 days following light damage. These results provide the first in vivo evidence that combined deficiency of Bax and Bak can rescue cells from a pathologic stimulus more effectively than Bax deficiency and suggest that combined deficiency of Bax and Bak may also protect cells from other insults.Cell Death and Differentiation (2004) 11, 1192-1197. doi:10.1038/sj.cdd.4401486 Published online 23 July 2004 [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
