Circulating IL‐4, IFNγ and IL‐17 conventional and Innate‐like T‐cell producers in adult asthma.

Autor: Leite‐de‐Moraes, Maria, Belo, Renata, Dietrich, Céline, Soussan, David, Aubier, Michel, Pretolani, Marina
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Zdroj: Allergy; Dec2020, Vol. 75 Issue 12, p3283-3286, 4p
Abstrakt: Circulating IL-4, IFN and IL-17 conventional and Innate-like T-cell producers in adult asthma Abbreviations ACT Asthma control test ALL All asthmatics FEV 1 Forced expiratory volume in one sec FVE Forced vital capacity GINA Global Initiative for Asthma HD Healthy donors ICS Inhaled corticosteroids IFN Interferon- IL Interleukin IL-17 Interleukin-17A ILT innate-like T cells iNKT invariant Natural Killer T cells MAIT Mucosal-associated invariant T cells MAIT17 IL-17-producing Mucosal-associated invariant T cells MOD mild-to-moderate asthmatics OCS Oral corticosteroids SEV Severe asthmatics Tc1 Type 1 cytotoxic CD8 + T cells Tc2 Type 2 cytotoxic CD8 + T cells TCR T-cell receptor Th T helper Compelling evidence outlined the importance of conventional T-helper (Th)2 and Th17 CD4 SP + sp T cells and of innate-like T cells (ILT), namely invariant natural killer T (iNKT), T and mucosal-associated invariant T (MAIT) cells, as sources of inflammatory cytokines involved in asthma pathology.1-5 Ideally, the analysis of the major inflammatory cells implicated in asthma severity should be performed in the airways. To better understand the possible contribution of these cells in the context of ICS use and atopic markers, we analysed the ratios Th1/Th2, Th2/Th17 and Th1/Th17. Further, the ratios Th1/Treg, Th17/Treg and, to a lesser extent, Th2/Treg showed that these activated T cells were over-represented in ALL compared to HD (Figure S2B to D). [Extracted from the article]
Databáze: Complementary Index
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