| Abstrakt: |
The development of new imaging agents able to differentiate tissue, organs, or pathologies more efficiently and presenting good biocompatibility motivates new studies due to its huge importance in the medical field. On the another hand, near-infrared (NIR) fluorescent probes offer advantages such as very high sensitivity, high photon penetration, low-light scattering, and minimal autofluorescence from living tissues, whereas magnetic resonance imaging (MRI) offers better resolution. In this context, this work aimed to obtain particles based on niobium oxide doped with Gd3+ (1, 6, and 10%) and Tm3+ (3%) by the nonhydrolytic sol–gel to be applied as contrast agents as well as nanoprobes for biolabelling. The structure, luminescent properties, and T1/T2 relaxivity behavior were investigated using scanning electron microscopy, X-ray diffraction, fluorimeter, FTIR and Raman spectroscopies, dynamic light scattering, and MRI techniques. Highlights: The nonhydrolytic sol–gel route is a simple methodology to obtain different hosts for applications in nanomedicine. Niobium oxide doped with gadolinium doped into can be obtained by the nonhydrolytic sol–gel methodology. Thulium emission in the infrared can be used in diagnostic imaging. [ABSTRACT FROM AUTHOR] |
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