Pentamidine sensitizes FDA-approved non-antibiotics for the inhibition of multidrug-resistant Gram-negative pathogens.

Autor:	Wu, Chenxuan, Xia, Ling, Huang, Wei, Xu, Yangfan, Gu, Yuanxin, Liu, Chang, Ji, Luting, Li, Wenyao, Wu, Yandong, Zhou, Kai, Feng, Xinxin
Předmět:	GRAM-negative bacteria ENTEROBACTER cloacae MITOMYCIN C CAENORHABDITIS elegans ANTI-infective agents ESCHERICHIA coli
Zdroj:	European Journal of Clinical Microbiology & Infectious Diseases; Sep2020, Vol. 39 Issue 9, p1771-1779, 9p
Abstrakt:	Pentamidine sensitizes FDA-approved antibiotics to combat Gram-negative pathogens. We screened 1374 FDA-approved non-antibiotics for their ability to be sensitized by pentamidine against Escherichia coli. We identified mitomycin C and mefloquine as potent hits effective against multiple drug-resistant, Gram-negative bacteria. Killing kinetics and an in vivo model with Caenorhabditis elegans (C. elegans) revealed that such combinations produced synergy against colistin-resistant Enterobacter cloacae (E. cloacae). These findings suggest combinations of FDA-approved non-antibiotics, and pentamidine can be repurposed into new antimicrobial agents. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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