| Autor: |
Ahmed, Manar M., Abd-Allah, Wesam M., Omar, Areg E., Soliman, Ahmed A. F. |
| Předmět: |
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| Zdroj: |
Journal of Inorganic & Organometallic Polymers & Materials; Sep2020, Vol. 30 Issue 9, p3646-3657, 12p |
| Abstrakt: |
Nano bioactive glasses in the system; 70 SiO2–10 P2O5–(20–x) CaO–xCuO (x = 0, 3 and 5% mol%), were synthesized by the rapid alkali sol–gel method. The dual effect of incorporating 0, 3, and 5 mol% of CuO (replacing CaO) and gamma irradiation on nanobioactive glasses structure were studied. The bioactivity, cytotoxicity and promotion in wound healing of fibroblast cells (BJ-1) were studied. The results showed that the unirradiated and irradiated samples were able to form hydroxyapatite layer on their surfaces in SBF after 30 days. Scratch-wound healing assay also, indicated that the samples which incorporating 3 mol% of CuO with or without gamma irradiation had the highest wound closure rate (99.1%, and 98.1%, respectively). The result of cytotoxic assay demonstrated that 100 μg/mL of 0, 3 mol% of CuO before and after gamma irradiation showed non-significant decrease (p > 0.05) in the mean viability percentage towards BJ.1 cells. Therefore, these compositions could be suitable for wound healing applications. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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