| Autor: |
Baptista, Abrahão Fontes, Baltar, Adriana, Okano, Alexandre Hideki, Moreira, Alexandre, Campos, Ana Carolina Pinheiro, Fernandes, Ana Mércia, Brunoni, André Russowsky, Badran, Bashar W., Tanaka, Clarice, de Andrade, Daniel Ciampi, da Silva Machado, Daniel Gomes, Morya, Edgard, Trujillo, Eduardo, Swami, Jaiti K., Camprodon, Joan A., Monte-Silva, Katia, Sá, Katia Nunes, Nunes, Isadora, Goulardins, Juliana Barbosa, Bikson, Marom |
| Předmět: |
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| Zdroj: |
Frontiers in Neurology; 11/25/2020, Vol. 11, pN.PAG-N.PAG, 18p |
| Abstrakt: |
Background: Novel coronavirus disease (COVID-19) morbidity is not restricted to the respiratory system, but also affects the nervous system. Non-invasive neuromodulation may be useful in the treatment of the disorders associated with COVID-19. Objective: To describe the rationale and empirical basis of the use of non-invasive neuromodulation in the management of patients with COVID-10 and related disorders. Methods: We summarize COVID-19 pathophysiology with emphasis of direct neuroinvasiveness, neuroimmune response and inflammation, autonomic balance and neurological, musculoskeletal and neuropsychiatric sequela. This supports the development of a framework for advancing applications of non-invasive neuromodulation in the management COVID-19 and related disorders. Results: Non-invasive neuromodulation may manage disorders associated with COVID-19 through four pathways: (1) Direct infection mitigation through the stimulation of regions involved in the regulation of systemic anti-inflammatory responses and/or autonomic responses and prevention of neuroinflammation and recovery of respiration; (2) Amelioration of COVID-19 symptoms of musculoskeletal pain and systemic fatigue; (3) Augmenting cognitive and physical rehabilitation following critical illness; and (4) Treating outbreak-related mental distress including neurological and psychiatric disorders exacerbated by surrounding psychosocial stressors related to COVID-19. The selection of the appropriate techniques will depend on the identified target treatment pathway. Conclusion: COVID-19 infection results in a myriad of acute and chronic symptoms, both directly associated with respiratory distress (e.g., rehabilitation) or of yet-to-be-determined etiology (e.g., fatigue). Non-invasive neuromodulation is a toolbox of techniques that based on targeted pathways and empirical evidence (largely in non-COVID-19 patients) can be investigated in the management of patients with COVID-19. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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