Platelet-Rich Plasma (PRP) Bio-Stimulant Gel Dressing In Treating Chronic Non-Healing Leg and Foot Ulcers; Cost and Effectiveness. Randomized Controlled Clinical Trial.

Autor: Habeeb, Tamer A. A. M., Elsayed, Ashraf Abdelmonem, Mohamed, Hany, Abdelhamid, Mohamed I.
Předmět:
Zdroj: Surgical Chronicles; Jul-Sep2020, Vol. 25 Issue 3, p210-216, 7p
Abstrakt: Background: Chronic non-healing leg and foot ulcers had considerable morbidity. Platelet-rich plasma (PRP) release various growth factors that can modulate healing process. PRP is a simple, safe, effective procedure for different types of chronic ulcer. The aim: to evaluate and compare between PRP dressing and traditional dressing in the treatment of chronic non-healing leg and foot ulcers of different etiologies as regards the cost of overall treatment (number of dressings) and effectiveness (reduction of the size of the ulcer in cm). Methods: Patients were divided into group A: received PRP dressing (N=22) and group B: received traditional ordinary dressing (N=22). Patients treated with PRP at the once-weekly interval for a maximum of 12 dressings while patients with ordinary dressings may need one dressing every other day for a maximum of 12 weeks. The reduction in the size of the ulcers in both groups was assessed using a centimeter-scale and Digital photographs before each session. The number of dressings in every patient was calculated. Results: In Group A (22 patients): 18 patients (82%) were completely healed at a variable time till the end of the study (12th week). Non-healing ulcers in 4 patients (15%). one case healed with more 2 dressings at the end of the14th week and the three cases healed after skin grafting. Group B: 14 patients (64%) were completely healed at the end of the study (12th week).non-healing ulcers in 8 patients (36%).two cases healed with more dressings at the end of the 17th week, two cases with skin graft and the last 4 cases healed after PRP dressing once weekly for 4 dressings. Conclusion: PRP gel dressing once weekly showed significant benefit regarding the healing rate of the ulcer and reduction of the overall treatment cost. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index