| Autor: |
Parviainen, Anna, But, Anna, Siljander, Heli, Knip, Mikael, Groop, Per-Henrik, Ilonen, Jorma, Otonkoski, Timo, Veijola, Riitta, Abram, Alar, Aito, Henrikka, Arkhipov, Ivan, Blanco-Sequeiros, Elina, Bondestam, Jonas, Granholm, Markus, Haapalehto-Ikonen, Maarit, Horn, Torsten, Huopio, Hanna, Janer, Joakim, Johansson, Christian, Kalliokoski, Liisa |
| Zdroj: |
Diabetes Care; Dec2020, Vol. 43 Issue 12, p2953-2958, 6p |
| Abstrakt: |
Objective: The incidence of type 1 diabetes has been rising for decades, particularly among young children. Between 2006 and 2011, the incidence rate (IR) reached a plateau in Finland. In this observational, register-based cohort study, we assess recent trends in the disease rate in Finnish children.Research Design and Methods: Based on data from the Finnish Pediatric Diabetes Register, we studied the incidence of type 1 diabetes among children younger than 15 years of age between 2003 and 2018. We assessed sex-specific IRs per 100,000 person-years (PY) by 4-year time periods in three age-groups (0.50-4.99, 5.00-9.99, and 10.00-14.99 years).Results: Among the 7,871 children with newly diagnosed type 1 diabetes, the median age at diagnosis increased from 7.88 to 8.33 years (P = 0.001), while the overall IR decreased from 57.9/100,000 PY in 2003-2006 to 52.2/100,000 PY in 2015-2018, yielding an IR ratio (IRR) of 0.90 (95% CI 0.85-0.96, P = 0.001). This decline was mainly due to the decrease in the youngest age-group (IRR 0.77 [95% CI 0.68-0.87]; P < 0.001), being significant both among boys and girls. In the middle age-group, a significant decrease was observed only among girls. No changes were observed in the oldest children.Conclusions: The incidence of type 1 diabetes decreased among young Finnish children between 2003 and 2018. Current findings imply that environmental factors driving the immune system toward islet autoimmunity are changing in young children. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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