Pallidal deep brain stimulation in primary Meige syndrome: clinical outcomes and psychiatric features.

Autor:	Qingpei Hao, Dongliang Wang, Jia OuYang, Hu Ding, Gaungyong Wu, Zhi Liu, Ru'en Liu, Hao, Qingpei, Wang, Dongliang, OuYang, Jia, Ding, Hu, Wu, Gaungyong, Liu, Zhi, Liu, Ru'en
Předmět:	DEEP brain stimulation BRAIN stimulation PULSE generators GLOBUS pallidus NEUROREHABILITATION NEURAL stimulation MENTAL illness ELECTRODES RESEARCH NEUROLOGICAL disorders BASAL ganglia DIZZINESS RESEARCH methodology ARTIFICIAL implants SURGICAL complications DEGLUTITION disorders RETROSPECTIVE studies MEDICAL cooperation EVALUATION research SELF-report inventories HEALTH surveys SLEEP GAIT disorders TREATMENT effectiveness ARTICULATION disorders COMPARATIVE studies PSYCHOLOGICAL tests QUALITY of life NUMBNESS MENTAL depression QUESTIONNAIRES MEIGE syndrome
Zdroj:	Journal of Neurology, Neurosurgery & Psychiatry; Dec2020, Vol. 91 Issue 12, p1343-1348, 6p
Abstrakt:	Objectives: To study the efficacy and safety of bilateral globus pallidus internus deep brain stimulation (GPi-DBS) in refractory Meige syndrome (MS) and evaluate the psychiatric disorders before and after surgery.Methods: Twenty-two patients with MS treated with bilateral GPi-DBS were retrospectively analysed before surgery and after continuous neurostimulation. Before surgery, patients were assessed by the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS), Self-Rating Depression Scale, Medical Outcomes Study 36-Item Short-Form General Health Survey (SF-36) and Pittsburgh Sleep Quality Index (PQSI), which corresponded to motor symptoms, depressive state, quality of life and sleep quality, respectively. The implantable pulse generator of each patient was activated at 1 month after surgery. At 1 month, 3 months, 6 months and 12 months after continuous neurostimulation, all patients were evaluated by the same scales above.Results: The BFMDRS movement scores decreased from 15.0±5.3 before surgery to 3.5±4.5 at 12 months after neurostimulation, with a mean improvement of 78% (p<0.001). The BFMDRS disability scores improved from 7.4±4.9 before surgery to 4.0±4.6 at 12 months after neurostimulation, with a mean improvement of 56% (p<0.001). The postoperative SF-36 scores had the remarkable improvement compared with baseline scores. Impaired sleep quality was found in 82% of patients and depression in 64% before surgery, which didn't neither obtained amelioration after continuous neurostimulation.Conclusions: Bilateral pallidal neurostimulation is a beneficial therapeutic option for refractory MS, which could improve the motor symptoms except for depression and sleep quality. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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