| Autor: |
Murao, Satoshi, Makino, Hideichi, Kaino, Yukikazu, Konoue, Etsushi, Ohashi, Jun, Kida, Kaichi, Fujii, Yasuhisa, Shimizu, Ikki, Kawasaki, Eiji, Fujiyama, Masao, Kondo, Shiori, Tanaka, Kiyonobu, Tarumi, Yoshinao, Seto, Isamu, Kato, Kenichi, Ohno, Keizo, Kusunoki, Yukiko, Ebisui, Osamu, Takada, Yasuharu, Tanabe, Katsuya |
| Předmět: |
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| Zdroj: |
Diabetes; Oct2004, Vol. 53 Issue 10, p2684-2690, 7p, 3 Charts |
| Abstrakt: |
To clarify heterogeneity in Japanese adult-onset type 1 diabetes, we analyzed the HLA-DR and -DQ haplotypes, depending on the clinical phenotype, and compared them with those in childhood-onset type 1 diabetes (CO). The patients in a previously reported Ehime Study were divided into subgroups by the mode of onset of diabetes: 68 acute-onset type 1 diabetic patients (AO) and 28 slowly progressive type 1 diabetic patients (SO). HLA haplotypes were compared with those of 80 CO patients and 190 control subjects. Two major susceptible HLA haplotypes in the Japanese, DRB1*0405-DQB1*0401 (DR4) and DRB1*0901-DQB1*0303 (DR9), were significantly increased in the AO and CO groups, but only DR9 was increased in the SO group. AO subjects had a higher frequency of DR9 than CO subjects. Accordingly, the DR9:DR4 frequency increased with increasing age of onset. Another susceptible haplotype, DRB1*0802-DQB1*0302 (DR8), was involved only in the CO group. Analysis of haplotype combinations revealed that DR4 and DR9 had significant dosage effects on the AO and CO groups (P < 0.0001), but only DR9 had such an effect in the SO group (P < 0.03). These results suggest differences in the contribution of HLA class II haplotypes to susceptibility of type 1 diabetes depending on the clinical phenotype and also indicate that HLA class II haplotypes may be associated with the onset age of type 1 diabetes. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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