Pomalidomide and dexamethasone grant rapid haematologic responses in patients with relapsed and refractory AL amyloidosis: a European retrospective series of 153 patients.

Autor: Milani, Paolo, Sharpley, Faye, Schönland, Stefan O., Basset, Marco, Mahmood, Shameem, Nuvolone, Mario, Kimmich, Christoph, Foli, Andrea, Sachchithanantham, Sajitha, Merlini, Giampaolo, Wechalekar, Ashutosh, Palladini, Giovanni, Hegenbart, Ute
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Zdroj: Amyloid; Dec2020, Vol. 27 Issue 4, p231-236, 6p
Abstrakt: Pomalidomide demonstrated activity in the treatment of AL amyloidosis in three phase II clinical trials. We evaluated the safety and efficacy of 28-day cycles of pomalidomide and dexamethasone in 153 previously treated patients with systemic AL amyloidosis. Ninety-nine (65%) were refractory to the last line of therapy and 54 (35%) had relapsed. The median number of previous lines of therapy was 3 (range: 2–7): 143 patients (93%) previously received bortezomib, 124 (81%) lenalidomide, 114 (75%) oral melphalan, and 37 (24%) underwent autologous stem cell transplant. At the completion of cycle 6, 68 (44%) patients obtained at least partial haematologic response, with 5 complete responses (CR, 3%), 35 very good partial responses (VGPR, 23%). Haematologic response resulted in improved overall survival (median survival 50 vs. 27 months, p =.033) in a 6 months landmark analysis. Obtaining at least partial response was also associated with a significant improvement of the progression-free survival (median PFS 37 vs. 18 months, p <.001). Pomalidomide is an effective treatment for heavily pre-treated patients with AL amyloidosis. Haematologic responses are associated with an overall survival advantage. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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