| Autor: |
Korenromp, Eline L., Armstrong-Schellenberg, Joanna R. M., Williams, Brian G., Nahlen, Bernard L., Snow, Robert W. |
| Předmět: |
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| Zdroj: |
Tropical Medicine & International Health; Oct2004, Vol. 9 Issue 10, p1050-1065, 16p |
| Abstrakt: |
To review the impact of malaria control on haemoglobin (Hb) distributions and anaemia prevalences in children under 5 in malaria-endemic Africa.Literature review of community-based studies of insecticide-treated bednets, antimalarial chemoprophylaxis and insecticide residual spraying that reported the impact on childhood anaemia. Anaemia outcomes were standardized by conversion of packed cell volumes into Hb values assuming a fixed threefold difference, and by estimation of anaemia prevalences from mean Hb values by applying normal distributions. Determinants of impact were assessed in multivariate analysis.Across 29 studies, malaria control increased Hb among children by, on average, 0.76 g/dl [95% confidence interval (CI): 0.61–0.91], from a mean baseline level of 10.5 g/dl, after a mean of 1–2 years of intervention. This response corresponded to a relative risk for Hb < 11 g/dl of 0.73 (95% CI: 0.64–0.81) and for Hb < 8 g/dl of 0.40 (95% CI: 0.25–0.55). The anaemia response was positively correlated with the impact on parasitaemia (P = 0.005,P = 0.008 andP = 0.01 for the three outcome measures), but no relationship with the type or duration of malaria intervention was apparent. Impact on the prevalence of Hb < 11 g/dl was larger in sites with a higher baseline parasite prevalence. Although no age pattern in impact was apparent across the studies, some individual trials found larger impacts on anaemia in children aged 6–35 months than in older children.In malaria-endemic Africa, malaria control reduces childhood anaemia. Childhood anaemia may be a useful indicator of the burden of malaria and of the progress in malaria control. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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