| Autor: |
YUKI MUKAI, YUMIKO MINAGAWA, HIROMI INOUE, AKIKO SATO, KENGO MATSUI, TAKANORI FUKUDA, KAZUYA ONUMA, HIDEYUKI HONGO, RYOSUKE SHIRATA, HIRONORI NAGATA, HARUMITU HASHIMOTO, TOMIO INOUE, MASAHARU HATA, MOTOKO OMURA |
| Předmět: |
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| Zdroj: |
In Vivo; Nov/Dec2020, Vol. 34 Issue 6, p3387-3398, 12p |
| Abstrakt: |
Background/Aim: This study aimed to evaluate the clinical outcome of intensity-modulated radiation therapy (IMRT) and high-dose-rate intracavitary brachytherapy (HDR-ICBT) in uterine cervical cancer (UCC). IMRT consisted of whole-pelvic radiation therapy (WPRT) and sequential WPRT with central-shielding (WPRT-CS). Patients and Methods: Thirty UCC patients treated with IMRT using TomoTherapy, were retrospectively analyzed. Results: The median dose of WPRT and WPRT-CS was 36 and 14.4 Gy and the median total dose of these was 50 Gy in 25 fractions (Fr). Median HDR-ICBT dose/Fr to Point A was 25 Gy/5 Fr. Median 2 Gy per fraction-equivalent dose (EQD2) of combined WPRT and HDR-ICBT to Point A (α/β=10) was 71.0 Gy. The 3-year local control, disease-free survival, and overall survival rates were 89.9%, 83.3%, and 86.3%. Conclusion: IMRT of WPRT and WPRT-CS given in combination with HDR-ICBT was a feasible therapy resulting in good disease control and tolerance in patients with UCC. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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