| Autor: |
Geoffroy Gueswindé, OUEDRAOGO, Sylvain, ILBOUDO, Salfo, OUEDRAOGO, Jean Claude Romaric Pingdwendé, OUEDRAOGO, Gaëtan Donzéo, SOMDA, Sidiki, TRAORE, Lazare, BELEMNABA, Noufou, OUEDRAOGO, Félix Bondo, KINI, Marius, LOMPO, Innocent Pierre, GUISSOU, Sylvin, OUEDRAOGO |
| Předmět: |
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| Zdroj: |
Journal of Drug Delivery & Therapeutics; 2020 Supplement, Vol. 10, p40-50, 11p |
| Abstrakt: |
Sickle cell disease remains a major public health problem in Burkina Faso and Africa. For the management of this pathology in young children, the Institute for Research in Health Sciences has developed an herbal drug called FACA® syrup. The objective of this study was to verify the safety and pharmacological efficacy of this formulation for its use in the management of sickle cell disease. Acute and subacute oral toxicity tests were performed on Wistar rats in accordance with Organization for Economic Cooperation and Development test guidelines and anti-sickling activity of FACA® syrup was evaluated according to the Emmel test. In the acute test, FACA® syrup didn't cause mortality or any behavioral change at dose of 2000 mg/kg/b.w suggesting that the test product estimated LD50 is 5000 mg/kg b.w. The results of subacute toxicity study indicate that the daily administration of FACA® syrup during 28 days did not result in significant change on physical, haematological and biochemical parameters up to dose of 1000 mg/kg b.w. The evaluation of effect of FACA® syrup in vitro on sickling revealed that, FACA® syrup possesses a real antisickling activity. Regarding these results FACA® syrup would be considered as safe in both acute and subacute exposure and could be used in the management of sickle cell diseases. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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