Oxidative DNA Cleavage by Free and Oligonucleotide-Conjugated O-Bromobenzoic Acid in the Presence of Copper(II) Ions.

Autor:	Koval, O.A., Oleinikova, S.B., Litvak, V.V., Vlassov, V.V., Chernolovskaya, E.L.
Předmět:	BENZOIC acid REACTIVE oxygen species OLIGONUCLEOTIDES COPPER DNA
Zdroj:	Nucleosides, Nucleotides & Nucleic Acids; Jun2004, Vol. 23 Issue 6/7, p849-853, 5p, 2 Black and White Photographs, 1 Graph
Abstrakt:	o-Bromobenzoic acid was found to promote copper-dependent reactive oxygen species formation from molecular oxygen, resulting in DNA base modification and backbone cleavage. The oligonucleotide conjugate bearing 5-(4′-aminopropyl-sulfomoyl)-2-bromobenzoic acid as a reactive group was synthesized and DNA cleavage activity of this oligonucleotide conjugate was tested on a model deoxyoligonucleotide. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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