Binding Properties of the Conjugates of Oligo(2′-O-Methylribonucleotides) with Minor Groove Binders Targeted to Double Stranded DNA.

Autor:	Novopashina, D.S., Sinyakov, A.N., Ryabinin, V.A., Venyaminova, A.G., Perrouault, L., Brunet, E., Giovannangeli, C., Boutorine, A.S.
Předmět:	PYRIMIDINES NUCLEOTIDES DNA PROTEIN binding MOLECULAR structure
Zdroj:	Nucleosides, Nucleotides & Nucleic Acids; Jun2004, Vol. 23 Issue 6/7, p1015-1022, 8p, 2 Diagrams, 1 Chart, 3 Graphs
Abstrakt:	Design, synthesis, physico-chemical and in vitro biological studies of new pyrimidine oligo(2′-O-methylribonucleotide) conjugates with oligocarboxamide minor groove binders(MGB) and benzoindoloquinoline intercalator(BIQ) are described. These conjugates formed stable triple helices with the target double-stranded DNA and inhibited its in vitro transcription upon binding. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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