| Abstrakt: |
Hypothyroidism is a systemic disease resulted from anatomical or functional absence of thyroid gland. Levothyroxine (LT4) is the principal substitution treatment in hypothyroidism. Overtreatment of hypothyroidism with levothyroxine has many adverse consequences. Also, several medications, supplements and foods can interfere with the absorption and action of levothyroxine. Caraway considered one of the plants which can cause leanness, hand tremor, tachycardia, sweating,if ingested for prolong periods. These impacts are similar to that of hyperthyroid symptoms.Cariumcarviwhere extracted; chemical analysis of the extract where done (Phytochemical screening tests and Gas chromatography-mass spectrometry (GC-MS) analysis). Thyrotropic activity of ethanolic caraway seeds extract has been studied by using two doses of caraway seed extract 1000 and 2000mg/kg and compare with control group (DMSO10ml/kg), hypothyrodisim group (propylthiouracil PTU 10mg/ kg) and standard treatment therapy group (LT4 15 mcg/kg). The GC-MS analysis revealed the presence of carvone and limonene.In comparsion to hypothyroid group, the extract cause significant reduction thyroid stimulating hormone (TSH), total cholesterol (TC) levels and significant elevation in in thyroxin (T4 ), deiodinase type 1 (DIO1), glucose-6-phosphatase (G6pase) levels, while malondialdhyde (MDA) were slightly reduced and catalase (CAT) slightly raised. Light microscopical observation of thyroid tissue illustrated that group which received antithyroid agent (propylthiouracil) for 14 days, show distorted and hypertrophied thyroid follicles when compared with control that show no change in thyroid follicles. After treatment of hypothyroidism with levothyroxine for two weeks, thyroid follicles return more or less to normal size. This finding consists with that of the last two groups, which received caraway seed extract at different doses for the same period. Caraway seeds extract showed stimulatory effects on the thyroid gland, suggesting its beneficial role in treating hypothyroidism. [ABSTRACT FROM AUTHOR] |
