| Abstrakt: |
This study was conducted to find out hepatoprotective activity of berberine (BRB) 50,100mg/kg body weight (b.w.) against oxytetracycline (OXT) 200 mg/kg induced hepatic toxicity in rats. Thirty two male rats were divided into four groups, group1: control (1 ml/kg Saline orally) group 2: OXT (200 mg/kg), intraperitoneally (i.p.) for (7) consecutive days, group 3: OXT (200 mg/kg), i.p. plusBRB (50 mg/kg) orally for (7) consecutive days, group 4: OXT (200 mg/kg), i.p. plus BRB (100 mg/ /kg) orally for (7) consecutive days. All the rats were killed on the (8) day of the experiment, and then the blood, and livers samples were taken. OXTinduced hepatic damage was proved by a significant (p e” 0.01) reduction in the body weight,and a significant (p ≤ 0.01) increased serum aspartate transaminase (AST), alanine transaminase (ALT), Malonaldehyde enzyme (MAD) and histopathological, immunohistochemical changes. Protective hepatic toxicity effect and oxidative damage caused by OXT significantly (p ≤ 0.01) increasing in body weight and significantly (p ≥ 0.01) decreasing AST, ALT, MAD and improving tissue morphology in BRB (50 mg//kg) while, BRB (100 mg//kg) has more impact. These results confirm that BRB (100 mg/ /kg) antioxidant effects can protect OXT -induced hepatotoxicity in rats. [ABSTRACT FROM AUTHOR] |
