INVESTIGATION OF NUCLEIC ACID TARGET TO 1,3,4-THIADIAZOLE DERIVATIVE BY USING DOCKING STUDIES.

Autor: AL-Azzawi, Ammar M. K., Ibraheem, Tareq K., Abdul Razaq, Waseela A., Fadil, Ghada S.
Předmět:
Zdroj: Biochemical & Cellular Archives; 2020Supplement2, Vol. 20, p3229-3231, 3p
Abstrakt: This work has been carried out in order to achieve the fullest possibilities of DNA targeting for numerous medical purposes. In this work, synthesized five membered heterocyclic derivatives via reaction terphathalic acid with two moles of thiosemicabazide in the presence POCl3 and synthesized Schiff bases from reaction compound preparation with p-ch, hlorobenzaldehyde. Interacting’s between the molecule and the DNA-receptor were examined by using molecular operating program docking studies to demonstrate binding with auto dock vina by molecular docking. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index