| Abstrakt: |
This study was conducted to find out hepatoprotective activity of berberine (BRB) 50, 100mg/kg body weight (b.w.) against gentamicin (GNT) 80 mg/kg induced hepatic toxicity in rats. Twenty eighty male rats were divided into four groups, group1: control, (1 ml/kg Saline orally) group 2: GNT (80 mg/kg), intraperitoneally (i.p.) for (7) consecutive days, group 3: GNT (80 mg/kg), i.p. plus BRB (50 mg//kg) orally for (7) consecutive days, group 4: GNT (80 mg/kg), i.p. plus BRB (100 mg//kg) orally for (7) consecutive days. All the rats were killed on the (8) day of the experiment, and then the blood, and livers samples were taken. GNT induced hepatic damage was proved by a significant (p ≤ 0.01) reduction in the body weight, and a significant (p ≤ 0.01) increased serum aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), Malonaldehyde enzyme (MAD) and histopathological, changes. Protective hepatic toxicity effect and oxidative damage caused by GNT significantly (p ≤ 0.01) increasing in body weight and significantly (p ≤ 0.01) decreasing AST, ALT, ALP, MAD and improving tissue morphology in BRB (50 mg//kg) while, BRB (100 mg//kg) has more effects. These results assure that BRB (100 mg//kg) antioxidant effects can protect GNT -induced hepatotoxicity in rats. [ABSTRACT FROM AUTHOR] |
