Is brain arousal regulation a predictor of response to psychostimulant therapy in adult ADHD patients?

Autor:	Strauß, Maria, Reif, Andreas, Ulke, Christine, Paucke, Madlen, Sander, Christian, Hegerl, Ulrich, Weber, Heike, Heupel, Julia, Kopf, Juliane, Kittel-Schneider, Sarah
Předmět:	LOGISTIC regression analysis ODDS ratio
Zdroj:	European Archives of Psychiatry & Clinical Neuroscience; Dec2020, Vol. 270 Issue 8, p1073-1076, 4p, 2 Charts
Abstrakt:	We investigated whether baseline brain arousal instability during resting state EEG, using the Vigilance Algorithm Leipzig (VIGALL 2.1), can predict response to methylphenidate therapy in adult ADHD patients. An arousal stability score of the EEGs of 28 adult ADHD patients was calculated quantifying the extent of arousal decline. In logistic regression analysis, arousal stability score predicted response to MPH [odds ratio 1.28 (95% CI 1.0–1.65); p = 0.027]. In this pilot study, we demonstrated that arousal stability at baseline predicted methylphenidate treatment response, indicating that less stable arousal regulation during a 15-min EEG at rest increases the chance of treatment response. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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