| Autor: |
Aimaletdinov, Alexandr, Mindubaeva, Gulnur, Khalikova, Svetlana, Kabwe, Emmanuel, Salmakova, Alexandra, Alexandrova, Natalia, Rutland, Catrin, Rizvanov, Albert, Zakirova, Elena |
| Předmět: |
|
| Zdroj: |
Open Veterinary Journal; 2020, Vol. 10 Issue 3, p261-266, 6p |
| Abstrakt: |
Background: Tendon injuries are one of the most common causes of orthopedic disorders in horses. Such injuries involve a long course of treatment and recovery. The most promising method of treating these injuries is the use of recombinant proteins and gene therapy. Aim: In this work, we evaluated the therapeutic efficacy of plasmid DNA (pDNA) containing two species-specific coding sequences, i.e. vascular endothelial growth factor 164 (VEGF164) and fibroblast growth factor 2 (FGF2), in the treatment of severe damage to the tendon of the superficial digital flexor. Methods: A pDNA construct was used to restore the damaged superficial digital flexor tendon in the horse. Results: This study showed that the administration of pDNA encoding VEGF164 and FGF2 genes at the injury area increased the regenerative activities of the damaged tendon. Conclusion: This study shows the therapeutic properties of genetic constructs (pDNA) and contributes to the advancements in the use of these therapies. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
