| Autor: |
Watanabe, Mikiko, Risi, Renata, Tuccinardi, Dario, Baquero, Claudia J, Manfrini, Silvia, Gnessi, Lucio |
| Předmět: |
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| Zdroj: |
Diabetes/Metabolism Research & Reviews; Oct2020, Vol. 36 Issue 7, p1-2, 2p |
| Abstrakt: |
Evidence has lately emerged regarding an increased risk of SARS-CoV-2 with worse prognosis in patients with obesity, especially among the young. Weight excess is a well-established respiratory disease risk factor, and the newly reported correlation is therefore unsurprising. The underlying pathophysiology is likely multi-stranded, ranging from complement system hyperactivation, increased Interleukin-6 secretion, chronic inflammation, presence of comorbidities such as diabetes and hypertension, and a possible local, detrimental effect within the lung. Further understanding the link between obesity and SARS-CoV-2 is crucial, as this could aid proper tailoring of immunomodulatory treatments, together with improving stratification among those possibly requiring critical care. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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