| Autor: |
Li, Hui, Lu, Jianbo, Yan, Chengqiu, Xu, Liwei |
| Předmět: |
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| Zdroj: |
International Journal of Polymeric Materials & Polymeric Biomaterials; 2020, Vol. 69 Issue 18, p1157-1166, 10p |
| Abstrakt: |
To avoid the clearance of reticuloendothelial system (RES) and realize tumor-specific targeting drug delivery are still the main challenges for nanodrug delivery systems in treatment of tumor. Recently, cell membranes coated nanoparticles have garnered more and more attention because of their mimic ability with their source cells, which are very effective in tumor therapy. Herein, we fabricated a biomimetic nanodrug delivery system composed of paclitaxel (PTX)-loaded gelatin nanogels (GN) as the inner cores and HT-29 tumor cell membranes (TCMs) as the outer shells, noted as TCM/GN/PTX for the targeted therapy of colorectal carcinoma. The TCM/GN/PTX showed obvious core-shell nanostructure and effectively reduced the release of laden PTX. Due to the homotypic targeting ability of coated TCM, the TCM/GN/PTX could realize the selective targeting of the homotypic tumor cells, therefore, obviously improving the accumulation of PTX at tumor sites. After administration in HT-29 xenografts mouse models, the TCM/GN/PTX significantly suppressed the tumor growth by inducing the necrosis and apoptosis of tumor cells. Moreover, due to the coated TCM effectively avoided the premature release of PTX, the TCM/GN/PTX showed minimal side effects. As a result, this bioinspired strategy-based biomimetic platform can be a promising nanodrug delivery system for unique targeted therapy of colorectal carcinoma. A biomimetic nanodrug delivery system was fabricated for targeted colorectal carcinoma therapy. This bilayer system was composed of paclitaxel (PTX)-loaded gelatin nanogels (GN) as the inner cores and HT-29 tumor cell membranes (TCM) as the outer shells, noted as TCM/GN/PTX. Because of the tumor targeting ability of the coated TCM, TCM/GN/PTX could effectively accumulate at tumor sites. The in vivo antitumor activity results towards the HT-29 xenografts mouse models indicated that the TCM/GN/PTX could obviously suppress the tumor cells growth through causing the necrosis and apoptosis of tumor cells. In addition, since the TCM coating could avoid the premature release of the laden PTX, TCM/GN/PTX exhibited minimal side effects. The work presented here provides a promising strategy for effective targeted therapy of colorectal carcinoma. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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