| Abstrakt: |
This prospective cross sectional study aims to establish the histological changes in the endometrium in women suffering from postmenopausal bleeding (PMB)to exclude endometrial malignant changes. Forty patients were collectd from Al-Khansaa Teaching Hospital in Mosul from December 2017 to October 2018. Detailed history about the age, parity, obstetric, menstrual and drugs history was recorded. Dilatation and curettage under general anaesthesia was performed to obtain endometrial biopsy . The specimens were fixed in 10% neutral buffered formalin for 24 hours then processed to obtain tissue sections which were stained with Harris Hematoxylin and Eosin (H & E) and examined using light microscope. Statistical analysis of the results was done with significant level set as P <0.05. Most of patients with PMB (62.5%) were between 51 and 65 years, (92.5%) of them were multiparous, (37.5%) were obese and hypertensive. Diabetes mellites was observed in (12.5%).Histological findings revealed (30%) endometrial atrophy, simple endometrialhyperplasia without atypia (25%), with atypia was found in (5%) while endometrial carcinoma was observed in (10%) and the incidence of endometrial carcinoma increases with advanced menopausal age. We conclude that postmenopausal bleeding is a significant symptom and should not be neglected and the incidence is significantly associated with multiparty, menopausal age between 51 and 60 years, high BMI, hypertension, diabetes and thyroid dysfunction. Majority of patients with postmenopausal bleeding showed benign atrophic changes (30%) which is the most common cause, proliferative and secretory endometrium, endometrial polyp and simple endometrial hyperplasia without atypia. [ABSTRACT FROM AUTHOR] |
