| Autor: |
Sadek, Eman Mohamed, Tawfik, Nezar Rifaat, Hussein, Amal Kamal, Abdelhakeem, Mohamed Abdelrazek |
| Předmět: |
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| Zdroj: |
Indian Journal of Public Health Research & Development; Apr2020, Vol. 11 Issue 4, p585-590, 6p |
| Abstrakt: |
Background: Liquorice is one of the most commonly used medicinal herb in Egypt as it has many pharmacological activities including anti-inflammatory and anti-allergic effects that encourage its use in asthma. Aim: evaluate the efficacy and safety of aqueous liquorice extract in asthmatic patients. Method: our study included 127 asthmatic patients who were classified into 3 groups which are, group 1(placebo group) maintained at inhaled corticosteroids (ICs) and long-acting beta agonist (LABA) and received starch capsules (500 mg starch) three times daily as placebo, group 2 maintained at ICs and LABA and received liquorice capsules twice daily and group 3 maintained at ICs and LABA and received liquorice capsules three times daily and the study lasts 4 weeks. Blood and sputum eosinophils %, pulmonary function test asthma control test (ACT) score, serum potassium level and blood pressure were measured before and after the 4 weeks of the study. Results: Only 95 patients completed the study and the results showed that liquorice in group 2 and 3 resulted in no significant reduction in blood and sputum eosinophils %. However, it significantly improved Forced Vital Capacity %, Forced Expiratory Volume % in one second and ACT score. Neither blood pressure (systolic and diastolic), nor serum potassium level showed any change in group 2. However, there was a significant elevation in systolic and diastolic blood pressure and reduction in serum potassium level in group 3. Conclusions: liquorice significantly improved the pulmonary function in both the lower and higher doses used in the study, however the lower dose of the extract was safe and increasing this dose resulted in a significant elevation in systolic and diastolic blood pressure and reduction in serum potassium level. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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